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Genetics and Genomics in Medicine
The second edition of this textbook written for undergraduate students, graduate students and medical researchers, Genetics and Genomics in Medicine explains the science behind the uses of genetics and genomics in medicine today, and how it is being applied. Maintaining the features that made the first edition so popular, this second edition has been thoroughly updated in line with the latest developments in the field.DNA technologies are explained, with emphasis on the modern techniques that are revolutionizing the use of genetic information in medicine and indicating the role of genetics in common diseases.Epigenetics and non-coding RNA are covered in-depth as are genetic approaches to treatment and prevention, including pharmacogenomics, genetic testing, and personalized medicine.A dedicated chapter charts the latest insights into the molecular basis of cancers, cancer genomics and novel approaches to cancer detection.Coverage of genetic testing at the level of genes, chromosomes and genomes has been significantly expanded and updated.Extra prominence has been given to additional genomic analyses, ethical aspects, and novel therapeutic approaches.Various case studies illustrate selected clinical applications. Key FeaturesComprehensive and integrated account of how genetics and genomics affect the entire spectrum of human health and diseaseExquisite artwork illuminates the key concepts and mechanismsSummary points at the end of each chapter help to consolidate learningFor each chapter, an abundance of further reading to help provide the reader with direction for further studyInclusive online question bank to test understandingStandard boxes summarizing certain key principles in geneticsClinical boxes summarizing selected case studies, pathogenesis mechanisms or novel therapies for selected diseasesThis book is equally suited for newcomers to the field as well as for engineers and scientists that have basic knowledge in this field but are interested in obtaining more information about specific future applications..
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Ancestral Genomics : African American Health in the Age of Precision Medicine
A leading evolutionary historian offers a radical solution to racial health disparities in the United States. Constance B. Hilliard was living in Japan when she began experiencing joint pain.Her doctor diagnosed osteoarthritis—a common ailment for someone her age.But her bloodwork showed something else: Hilliard, who had never had kidney problems, appeared to be suffering from renal failure.When she returned to Texas, however, a new round of tests showed that her kidneys were healthy.Unlike the Japanese doctor, her American primary care provider had checked a box on her lab report for “African American.” As a scholar of scientific racism, Hilliard was perplexed.Why should race, which experts agree has no biological basis, matter for getting accurate test results?Ancestral Genomics is the result of Hilliard’s decade-long quest to solve this puzzle.In a masterful synthesis of evolutionary history, population genetics, and public health research, she addresses the usefulness of race as a heuristic in genomic medicine.Built from European genetic data, the Human Genome Project and other databases have proven inadequate for identifying disease-causing gene variants in patients of African descent.Such databases, Hilliard argues, overlook crucial information about the environments to which their ancestors’ bodies adapted prior to the transatlantic slave trade.Hilliard shows how, by analyzing “ecological niche populations,” a classification model that combines family and ecological histories with genetic information, our increasingly advanced genomic technologies, including personalized medicine, can serve African Americans and other people of color, while avoiding racial essentialism. Forcefully argued and morally urgent, Ancestral Genomics is a clarion call for the US medical community to embrace our multigenomic society.
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Genomics
Written primarily for 16-19 year old students, this primer aims to extend students' knowledge and inspire them to take their school-level learning further.It explores topics that are familiar from the curriculum and also introduces new ideas, giving students a first taste of the study of biology beyond school-level and demonstrating how concepts frequently encountered at school are relevant to and applied in current research.This is the ideal text to support students who are considering making the transition from studying biology at school to university. This Oxford Biology Primer will introduce students to the field of genomics and its applications.From the early days of the Human Genome Project, sequencing technology has rapidly developed and is now cheaper and more accessible than ever before.The resulting pervasive nature of these technologies make them more likely to be experienced by people as patients, consumers and citizens. The primer introduces the basic principles of genomics and then uses these to consider human genetics, through examples of some of the rare diseases linked to single genes.The impact of these rare diseases is far-reaching and the knowledge gained through genome sequencing is proving invaluable in their diagnosis.Genome sequencing is revolutionising the diagnosis and treatment of cancer, and the primer introduces students to some of the key breakthroughs which have taken place in recent years.These include the identification of specific genes indicating cancer risk, and the sequencing of tumours throughout treatment to identify further mutations and modify treatment accordingly. The primer aims to address a number of the ethical issues which are raised by this rapidly-growing area of biology.Students are challenged to consider some of the decisions they may need to make relating to these technologies in their own lives, and are given opportunities to explore different aspects of these issues in a way which allows discussion to be both informed and meaningful. The study of infectious disease is also feeling the impact of genomics: the primer discusses the concept of pathogen genome sequencing, and illustrates the various ways in which this can be used - for example, enabling us to find different solutions to infections, to track outbreaks of disease to their source, and to identify and possibly ultimately combat antibiotic resistance. Many of the major diseases which impact the global population are caused by parasites, which come in a wide variety of shapes and sizes.The primer introduces students to the importance of understanding parasite genomes.Parasite genome sequencing makes it possible to develop both new medicines, and new treatments such as gene drive systems to wipe out disease-causing mosquito populations. For many years, our views of classification and evolution have been based on observational techniques going back to Darwin and Linnaeus.Focusing on human evolution, the primer will open students' eyes to the ways in which genome sequencing is being used to reveal evolutionary links that have never before been recognised, and to elucidate the way humans spread out of Africa across the world.Students are not always aware of the role technological developments play in enabling the progress of science.The final chapter delves into how genome sequencing technologies have developed, considering both the speed of change in the technology, its implications for usefulness, availability and cost, and the growing issue of big data and how it can be manipulated.The different technologies described in this chapter are referenced throughout the book.
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Thompson & Thompson Genetics and Genomics in Medicine
First published in 1966, Thompson and Thompson Genetics and Genomics in Medicine has become an essential textbook for medical students, genetic counseling students, students in laboratory medicine, and more advanced trainees.With its focus on fundamental principles in human genetics and genomics and their application to medicine, the book has served many as a well-thumbed resource they return to over and over. Such students can continue to depend on this valuable text, joining those in newer fields of genome data analysis for all they need to know about genetics and genomics throughout their basic science training, clinical placements and beyond.Coverage includes new discoveries-such as the functional roles of non-coding RNAs, chromatin regulation and epigenetics-latest technologies, and new diagnoses they are enabling. Under an expanded title, this ninth edition has been completely revised by a new editorial team overseeing a large cadre of contributing authors.Support groups have also assisted to update illustrations featuring beautiful images of those living with genetic conditions. Comprehensive coverage of: genomes in biology and medicine; copy number and structural genomic variation; novel discoveries; latest technology; and new genetic diagnoses Over 40 clinical case studies, capturing the latest challenges of variable expression, pleiotropy, and complex disorders through new diagnostic strategies Full-color text, illustrations, updated line diagrams, and clinical photos End-of-chapter questions and comprehensive answers to challenge the reader to consolidate the material into practice and prepare for examinations USMLE-style and multiple choice questions available as part of the eBook An enhanced eBook version is included with purchase.The eBook allows you to access all the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud Updated and new clinical cases, supported with photography by the not-for-profit organization, Positive Exposure New content on growing role of sequencing and novel functional assays in diagnosis and screening of genetic conditions New chapter on Epigenetics Clearer and more precise terminology, in response to contemporary and evolving guidelines New sections describing the use (and need for) genetic information from diverse populations, including unique indigenous and founder populations, for diagnosis and management.
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What are fitness supplements?
Fitness supplements are products designed to support athletic performance, muscle growth, and overall health and wellness. They often come in the form of pills, powders, or liquids and contain a variety of vitamins, minerals, amino acids, and other ingredients that are believed to enhance physical performance and recovery. While some fitness supplements can be beneficial when used correctly and in conjunction with a healthy diet and exercise routine, it is important to consult with a healthcare provider before adding any new supplements to your regimen.
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Can fitness supplements affect fertility?
Yes, fitness supplements can affect fertility. Some supplements, such as anabolic steroids and high doses of certain vitamins, can disrupt hormone levels and potentially impact fertility in both men and women. It's important to consult with a healthcare professional before taking any fitness supplements, especially if you are trying to conceive. Additionally, maintaining a balanced diet and regular exercise routine is crucial for overall reproductive health.
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Can someone who is a beginner in fitness please help me with nutrition, including supplements, etc.?
Yes, as a beginner in fitness, it's important to focus on a balanced and nutritious diet that includes a variety of fruits, vegetables, lean proteins, whole grains, and healthy fats. It's also important to stay hydrated by drinking plenty of water throughout the day. As for supplements, it's best to consult with a healthcare professional or a registered dietitian to determine if you have any specific nutrient deficiencies that may require supplementation. In general, it's best to get nutrients from whole foods whenever possible, but some people may benefit from certain supplements such as vitamin D or omega-3 fatty acids.
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Could fitness supplements potentially affect fertility?
Yes, fitness supplements could potentially affect fertility. Some supplements may contain ingredients that can disrupt hormone levels or interfere with reproductive function. It is important to consult with a healthcare provider before taking any fitness supplements, especially if you are trying to conceive. Additionally, maintaining a balanced diet and healthy lifestyle is crucial for overall reproductive health.
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Plant Genomics
Introduction to the range of molecular techniques to investigate unique facets of plant growth, development, and responses to the environment Plant Genomics introduces the complex relationship between the genome, microbiome, genes, and epigenetics of plants, as well as the range of molecular techniques applicable to investigating the unique facets of plant growth, development, and response to the environment.State-of-the-art science in the field is discussed, as well as future outlooks on what the next decade is likely to bring.This book includes new techniques for modifying the plant genome and their impact on modifying plants to combat the impact of biotic and abiotic stresses, including those associated with climate change, new technologies including long and short read sequencing and proximity ligation and the combination of these technologies for assembling sequence data into chromosomes, a new chapter on the sequences of the chloroplast and mitochondrial genomes, and a dedicated chapter to epigenetics and the importance in gene regulation.Written by a highly qualified author with significant published research contributions to the field, Plant Genomics includes information on: Structure and information content of the chloroplast and mitochondrial genomes and their use in phylogenyUse of transcriptomes from various tissues to identify expressed sequences and their identification as genesFunction of small regulatory RNAs and long non-coding RNAs and involvement of small RNAs in the control of gene expressionEpigenetic silencing of transposable elements and their release by stress and cross-generational contribution of epigenetic variationUse of the pan-genome to assemble a comprehensive germplasm for a particular crop species Plant Genomics is an ideal textbook for undergraduate courses on plant biology, particularly those focusing on molecular descriptions, and a helpful auxiliary text to plant biology laboratory courses.It will also be of interest to students in plant molecular biology, agricultural and food sciences, and plant, food, and crop bioengineering.
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Introduction to Genomics
Our genome is the blueprint for our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism.Yet it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed.But how do we identify the genes that make up our genome?How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life?Introduction to Genomics is the most up-to-date and complete textbook for students approaching the subject for the first time.Lesk's engaging writing style brings a narrative to a disparate field of study and offers a fascinating insight into what can be revealed from the study of genomes.The book covers: the similarities and differences between organisms; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing.The Online Resource Centre accompanying Introduction to Genomics features: For students: - Extensive and imaginative weblems (web-based problems) for each chapter designed to give you practice with the tools required for further study and research in the field- Hints and answers to end-of-chapter problems and exercises support your self-directed learning- Guided tour of websites and major archival databanks in genomics offer a wealth of resources to springboard your own research - Journal club: links to related research articles on topics covered in the book are paired with engaging questions to improve your interpretation of the primary literature- Rotating figures allow you to visualize complex structuresFor registered adopters: - Downloadable figures from the book.
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Introduction to Genomics
Our genome is the blueprint for our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism.Yet it is more than a static information store: our genome is a dynamic, tightly regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed.But how do we identify the genes that make up our genome?How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life?Introduction to Genomics is the most up-to-date and complete textbook for students approaching the subject for the first time.Lesk's engaging writing style brings a narrative to a disparate field of study and offers a fascinating insight into what can be revealed from the study of genomes.The book covers: the similarities and differences between organisms; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing. Digital formats and resourcesThe book is available for students and institutions to purchase in a variety of formats, and is supported by online resources:· The e-book offers a mobile-compatible experience and convenient access along with functionality tools, navigation features, and links that offer extra learning support: www.oxfordtextbooks.co.uk/ebooks· Online resources, available for registered adopters, include downloadable figures and tables from the book· E-book and Trove formats are enriched with online resources for students, including extensive and imaginative weblems (web-based problems) for each chapter; hints and answers to end-of-chapter problems and exercises to support self-directed learning; a guided tour of websites and major archival databanks in genomics to springboard further research; Journal Club (links to related research articles on topics covered in the book paired with engaging questions); and rotating figures which allow readers to visualize complex structures.
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Computational Genomics with R
Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics.The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques.The text provides accessible information and explanations, always with the genomics context in the background.This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented.As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds.For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology.After reading:You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin.He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002.He has published an extensive body of work in this area.The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.
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Why can't supplements actually replace real vitamins and minerals?
Supplements cannot fully replace real vitamins and minerals because they often lack the full spectrum of nutrients found in whole foods. Whole foods contain a variety of vitamins, minerals, and other beneficial compounds that work together synergistically to support overall health. In contrast, supplements may only contain isolated nutrients, which may not be as effective when taken alone. Additionally, the body may not absorb nutrients from supplements as efficiently as it does from whole foods. Therefore, it is important to prioritize a balanced diet rich in whole foods to ensure optimal nutrient intake.
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Where can one buy sports nutrition supplements online?
Sports nutrition supplements can be purchased online from various retailers such as Amazon, GNC, Bodybuilding.com, and The Vitamin Shoppe. These websites offer a wide range of sports nutrition supplements including protein powders, pre-workout drinks, and recovery supplements. Additionally, many sports nutrition brands have their own online stores where customers can purchase their products directly. It is important to research and compare prices, reviews, and shipping options before making a purchase.
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What are some fitness nutrition tips?
Some fitness nutrition tips include consuming a balanced diet that includes a variety of fruits, vegetables, lean proteins, and whole grains. It's important to stay hydrated by drinking plenty of water throughout the day. Additionally, timing your meals and snacks around your workouts can help provide the necessary energy and nutrients for optimal performance. Lastly, it's important to listen to your body and fuel it with the nutrients it needs to support your fitness goals.
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How can fitness contribute to healing?
Fitness can contribute to healing by improving circulation, which helps deliver oxygen and nutrients to the body's tissues, aiding in the repair and recovery process. Exercise also releases endorphins, which can help reduce pain and improve mood, promoting a sense of well-being during the healing process. Additionally, staying active can help maintain muscle strength and flexibility, preventing further injury and promoting overall physical health.
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